![]() Luo Tianyi, who has over 5 million followers on Weibo, celebrated her birthday in July with fans. ![]() Compared to real-life stars, virtual idols grow up on UGC (user-generated content) and - to a point - are malleable to fans. These creations have provided content and helped her develop a personality controlled by the creator. Luo’s fans have been writing songs, composing music, and drawing illustrations for her. The event was a huge success, attracting thousands of fans to the arena. In 2019, she had a holographic concert with China’s top pianist, Lang Lang. In the nine years since her “outset,” virtual singer Luo Tianyi has become a virtual celebrity. As such, Jing Daily investigates whether a new era of idols is here and exactly how these virtual influencers can benefit brands. Hangzhou-based C-beauty giant Florasis released its namesake AI ambassador, domestic haircare label Centaine announced the virtual KOL Ling as its brand spokesperson, and China jewelry maker IDO created the digital idol Beco. Since the beginning of 2021, several other Chinese companies have turned to the stability of these digital partners. When they are “born,” they only have a voice and appearance developed digitally by their creators. They make realistic facial expressions and body movements and mimic the actions of a real person. Virtual idols are fully AI-developed characters that bear a close resemblance to humans but are powered by advanced animation technology. ![]() These influencers present a safer alternative to traffic stars like Kris Wu, Zhang Zhehan, Zhao Wei, and Lucas Huang, all currently caught up in scandals. As idols continue to be a key marketing strategy to drive company sales in China, local companies are experimenting with digitally-created KOLs. Photo: Tmall’s WeiboĪyayi, who was created in May of 2021, is one of the many AI influencers in China’s virtual idol industry, which grew to a value of $540 million in 2020, an increase of 70.3 percent year on year, and is expected to reach $970 million this year, according to data from iiMedia Research. Thus, GQ-ODN targeting Stat3 induces tumor cell apoptosis when delivered into tumor xenografts and represents a novel class of chemotherapeutic agents that holds promise for the systemic treatment of many forms of metastatic cancer.Ayayi partnered with Tmall Super Brand Day to release limited-edition NFT mooncakes and physical gift boxes for the Mid-Autumn Festival. ![]() Biochemical examination of tumors from GQ-ODN-treated mice demonstrated a significant reduction in Stat3 activation, levels of the antiapoptotic proteins Bcl-2 and Bcl-xL, and an 8-fold increase in the number of apoptotic cells compared with the tumors of placebo-treated mice. Similarly, whereas the mean volume of prostate tumor xenografts in placebo-treated mice increased 9-fold over 10 days, xenografts in GQ-ODN-treated mice increased by only 2-fold. Whereas the mean volume of breast tumor xenografts in placebo-treated mice increased >7-fold over 18 days, xenografts in the GQ-ODN-treated mice remained unchanged. ![]() To establish the effectiveness of GQ-ODN as a potential new chemotherapeutic agent, we systemically administered GQ-ODN (T40214 or T40231) plus polyethyleneimine or polyethyleneimine alone (placebo) by tail-vein injection into nude mice with prostate and breast tumor xenografts. When delivered into cells using polyethyleneimine as vehicle, GQ-ODN blocked ligand-induced Stat3 activation and Stat3-mediated transcription of antiapoptotic genes. GQ-ODN targeted Stat3 protein directly inhibiting its ability to bind DNA. We recently developed G-rich oligodeoxynucleotides, which form intramolecular G-quartet structures (GQ-ODN), as a new class of Stat3 inhibitor. Stat3 is a signaling molecular and oncogene activated frequently in many human malignancies including the majority of prostate, breast, and head and neck cancers yet, no current chemotherapeutic approach has been implemented clinically that specifically targets Stat3. ![]()
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![]() ![]() ![]() Since general flex play oftentimes results in a 2* 4 cost carry, Aphelios is very popular for those who pursue an AD line. Senna items: Rageblade, Giant Slayer, AD itemsĭueling Gunners, Teaming Up, Cybernetic Leech, You Have My Sword, Harmacist, Pandora’s Items, Red BuffĪnother top comp, if you can hit your 2* 4 cost units, you will be very strong!Īphelios seems to be one of, if not, the most reliable AD flex comps right now.Jayce items: Thief’s Gloves, Zeke’s Herald.Zeri items: Giant Slayer, Last Whisper, Infinity Edge, Deathblade, Guardbreaker, Guinsoo’s Rageblade.Late game you typically play 4 Gunner + tanks. Once again, early game item holders are Jhin, Tristana and Ashe as far as 1 and 2 cost units go, and make sure to play around whatever upgraded frontline you can get until you get to Sej/Shen. Zeke’s Herald is a good item in this comp because it stacks AD quicker, but make sure you have a good frontline to buy time for your Gunners to scale. This comp is the other flexible AD comp, and usually is a result of having an early Gunner start, whether it be through units or augments or both. Gunners are strong at all points of the game, so it makes sense that it is the top performing comp due to its simplicity and strength.īest Emblem/Spatula Holder: Urgot, Ekko, Legendaries To be added: Sorcs, Jhin Reroll, Viego Reroll, Jinx Reroll, Akshan Reroll, Piltover, Nasus Carry, Strategist, many more S: Gunners, Deadeye, Ionia Yasuo, Yordle Reroll, Void Kai’Sa,ī: Kalista Reroll, Karma Reroll, Noxus, Shurima, Rogue, * How to Actually get to Challenger * Best TFT Comps for Set 9 Patch 13.12 Catch his streams on Twitch or get coaching from him!īe on the lookout by bookmarking this page or subscribing to my YouTube for the latest news and comps.Ĭheck LEVELING GUIDE so you know what to do for each comp (includes reroll and Augments) He is the Set 5 MSI winner and reaches top 10 every set. We’ve brought Voids1n back to show us Set 9 comps. Updated 6/16 – SET 9 COMPS ARE HERE!! LET’S GO! Check out Augments guide as well for this patch ![]() ![]() Do not use an Oxford Academic personal account. When on the society site, please use the credentials provided by that society.If you see ‘Sign in through society site’ in the sign in pane within a journal: ![]() Many societies offer single sign-on between the society website and Oxford Academic. Society member access to a journal is achieved in one of the following ways: If you cannot sign in, please contact your librarian. If your institution is not listed or you cannot sign in to your institution’s website, please contact your librarian or administrator.Įnter your library card number to sign in.
![]() Video of Israel coming to a standstill on Holocaust Remembrance DayĪn article about the 2 minutes of reflection observed in Israel If you are looking for more information about these days, below are some links to kick off your research: ![]() These days mark days of reflection, remembrance, mourning, and celebration within the Jewish and Israeli communities and can often be the impetus for widespread anti-Semitism.Īs members of our WUSM community, it can be helpful to understand the significance of the next week for our Jewish colleagues and patients and be cognizant of our roles as allies to their community if the need arises, as we simultaneously anticipate an uptick in anti-Semitism and hope that it doesn’t occur. Yom HaShoah marks the beginning of 3 important days within the Jewish calendar, followed by Israeli Memorial Day (Yom HaZikaron) starting at sundown Tuesday, May 3rd and culminating with Israeli Independence Day (Yom Ha’atzmaut) starting sundown of May 4th. Some of you may have seen or observed the International Holocaust Day of Remembrance in January. I’m writing to make you all aware of Holocaust Remembrance Day (Yom HaShoah) occurring from sundown on Wednesday, April 27th to sundown Thursday, April 28th. Understanding Systemic Racism Curriculum.Faculty Diversity Scholars Program Faculty Diversity Scholars Program.Examples of Faculty Activities related to DEI. ![]() ![]() ![]() Maxfield D, Grenny J, McMillan R, Patterson K, Switzler A. When I first picked up this book, I thought that a crucial conversation was epitomized by. 6 Kerry Patterson, Joseph Grenny, Ron McMillan, and Al Switzler, Crucial confrontations: Tools for talking about broken promises, violated expectations. Here's how to instantly uplift your crucial conversations."e -Mark Victor Hansen, cocreator of the #1 New York Times bestselling series Chicken Soup for the SoulThe first edition of Crucial Conversations exploded onto the scene and revolutionized the way millions of people communicate when stakes are high. Silence Kills: The Seven Crucial Conversations for Healthcare. Kerry Patterson, Joseph Grenny, Ron McMillan, Al Switzler. ![]() ![]() Below is a preview of the Shortform book summary of Crucial Conversations by Kerry Patterson, Joseph Grenny, et al. Book Summary: Learn the key points in minutes. Covey, author of The 7 Habits of Highly Effective People"e The quality of your life comes out of the quality of your dialogues and conversations. Use this book to learn how to step up to failed promises and deal with them in a way that both solves the problem and saves relationships. Our Summaries Pricing About Log in SIGN UP PDF Summary:Crucial Conversations, by Kerry Patterson, Joseph Grenny, et al. This book deserves to take its place as one of the key thought leadership contributions of our time."e -from the Foreword by Stephen R. From the bestselling authors who taught the world how to have Crucial. The New York Times and Washington Post bestseller that changed the way millions communicate"e draws our attention to those defining moments that literally shape our lives, our relationships, and our world. Kerry Patterson, Joseph Grenny, Ron McMillan, and Al Switzler, Crucial Conversations: Tools for Talking When Stakes Are High, Second Edition (New York. ![]() ![]() This belief drives Mori to his drastic and ruthless strategies. Mori views the position of an organization's leader as both ruling them and being their slave. Mori proposing about killing the agency's president during the three companies conflict. As a result of the Port Mafia's prosperous control in Yokohama, Mori enjoys being held in high regard, either by respect, fear, or a mix of both, by his many subordinates. He and Kōyō converse the most often, and their partnership leads to Mori agreeing to spare Kyōka after she defects. Generally, he usually only regularly speaks with his two most active executives, Kōyō and Chūya, the former of which often the first to criticize Mori's eccentrics in the form of dry banter. This aligns with Mori's leeway towards the organization's most active, powerful members, allowing them a certain degree of 'freedom' and independence from his tight scrutiny. ![]() Mori celebrates with Kōyō and Chuya after the Guild war. Even then, according to Mori, "effort is what matters, results come second", in the face of Akutagawa's previous failure of capturing Atsushi Nakajima. This contributes to why he never punishes Akutagawa's rash behavior. As such, even when facing a certain degree of insubordination, Mori is willing to overlook some mistakes so long as the outcome benefits the Port Mafia. He does treat his subordinates with respect, valuing their skills and contributions to the organization and acknowledging their power. His intensity is so much that Lucy is paralyzed with fear when Mori confronts her. Once this facade disappears, Mori's intensity and willingness to do anything, even kill, become apparent and unsettling. Fukuzawa, his former ally, knows the depths of Mori's darkness, and he and Dazai are most often the ones to see straight through Mori's many pretenses including Fukuzawa asking him if he still lusts on young girls during their set-up meeting during the Guild war. Otherwise, it creates a certain distance between him and others, as if nothing they say ever fazes him. For the most part, acting like a 'normal' person makes those around him less wary, as when he's in public and needs to avoid suspicion. Mori's use of manners and polite conduct mostly attribute to maintaining a sense of control and power in any situation. Age and gender do not matter to Mori, but when it comes to his grander schemes, he has a history of manipulating children, as their inexperience makes it that much easier to control them. While a largely logical person who knows how to use words to his advantage, Mori is not above threats and intimidation typical of a cold, experienced mafioso. To Mori, a 'heart' only gets in the way of war, a belief leading to his irredeemable actions of using Yosano's ability and mentally breaking her during the Great War. Emotional manipulation and abuse have gotten Mori far in his motives at the cost of many lives, and by the time someone's realized they've been used, it's often too late for them to turn back. That said, his intelligence allows him to manipulate and abuse many people by appealing to their needs and wants. Mori never takes emotions into full account, the epitome of logical thinking and strategy. Consequently, these decisions leave a bloodstained path and have hurt and traumatized countless other people, with Yosano and Dazai being prime victims of his abuse. Mori always weights the gains and losses of his decisions, choosing the optimal solutions for the Port Mafia as a whole. However, his cruelty is not for cruelty's sake. ![]() Mori later reveals that not only is he good with strategies and planning, but also a cruel and merciless person capable of infusing fear on his enemies. Mori's merciless nature after killing the previous boss. While initially showing himself as an ordinary, clumsy and worried middle-aged man, he later shows more about his true character, keeping calm even when the other people trapped in Anne's room ran away, staying together with Atsushi and Jun'ichirō Tanizaki, and still maintaining his composure when the latter was captured. ![]() ![]() ![]() Today’s masks and respirators are radically more advanced than their predecessors from just a century ago … “Hitler will send no warning,” admonished the posters, “so always carry your gas mask.” The Benefits of a Modern Gas Mask Indeed, the British government had issued gas masks to every citizen, urging them to carry their masks daily. Instantly recognizable by almost anyone on Earth, they were cold comfort in the event of an unexpected attack. This became the standard during World War II.īy the end of World War II, gas mask use had skyrocketed among both military and civilians. It also protected against new biological warfare threats. It allowed the use of a separate, replaceable filter canister. This gas mask was lighter, less bulky, and fitted the face better than those used in World War I. In 1943, the British Army developed a more modern mask. Let’s start with a brief history of the gas mask. Military users may want a gas mask that offers a good tactical advantage. For example, your team may need state-of-the-art biohazard masks, a chemical gas mask, a nuclear gas mask, or masks that protect against all of the above. Make no mistake, these devices can and will save your life if used correctly and in combination with the right gear.ĭifferent masks protect against different dangers. Here at MIRA Safety, we appreciate just how much goes into designing, developing, and manufacturing a gas mask to withstand the very worst conditions. As a manufacturer of a gas mask, respirators and other personal protective equipment, we have performed extensive, hands-on testing for every gas mask and filter listed below. We do our best to break down complicated terminology into layman’s terms. When you’ve finished this guide, you’ll know everything you need to know about how a gas mask works, how key features and details differ between masks, and how to select the right mask for a variety of applications. These intricate devices can save lives in dangerous situations, but which gas mask is right for you?
![]() ANDREJ ISAKOVIC/AFP/POOL/AFP via Getty Images Lewis Hamilton celebrates after winning the Saudi Arabian Grand Prix. READ: Lewis Hamilton says he’s ‘not comfortable’ racing in Saudi Arabia “He is over the limit for sure,” added Hamilton when asked if Verstappen came into that category of driver. Rules kind of don’t apply, or they don’t think of the rules. “I’ve come across a lot of different characters and there’s a few at the top which are over the limit. “I’ve raced a lot of drivers through my life in the 28 years,” Hamilton told Sky Sports. Verstappen was handed a 10-second time penalty by stewards after the race after having already been hit with a five-second penalty during the grand prix for the incident that allowed him to get ahead of Hamilton earlier on lap 37. The pair came together on a number of occasions throughout the race, including one bizarre crash on lap 37 when Hamilton ran into the back of Verstappen, who was slowing down to allow his rival past after being told to concede first place due to an earlier racing incident. Please allow 6-8 days to receive a tracking number while your order is hand-crafted, packaged and shipped from our facility.Lewis Hamilton and Max Verstappen’s rivalry continued to heat up on Sunday – both on and off the track – at an action-packed Saudi Arabian Grand Prix, as the Mercedes driver won his third consecutive race to go level on points with the Dutchman in the driver standings with one race remaining in the Formula One season. Please allow 6-8 days to receive a tracking number while your order is hand-crafted, packaged and shipped from our facility. ![]()
![]() Despite the conventional ending, which has a tacky, tacked-on feel, the movie is designed for those who are more adventurous when it comes to romance. The Lake House also has the odd distinction of raising metaphysical questions without boasting an overly intelligent storyline. Yet I recognize that the screenplay is like Swiss cheese - riddled with holes, some of which are bigger and more distracting than others. I appreciate that it's trying to do a supernatural love story without falling into the schmaltz of Ghost. By keeping the human element of the film more important than the fantastical one, they ground The Lake House and allow us to overlook many of its contrivances. The Lake House lives and dies based on Reeves and Bullock. Really, though, their roles are peripheral. Of course, since The Lake House is rated PG, their chemistry is more "cute" than "sexy." Christopher Plummer and Shoreh Aghdashloo have supporting roles (he as Alex's famous architect father she as Kate's boss at a Chicago hospital). The spark that ignited between them in Speed still burns - they make an appealing couple. The Lake House represents the reunion of Keanu Reeves and Sandra Bullock, who were last seen discussing the potential future of a relationship that starts under tense circumstances. Such lapses by the screenplay are unforgivable. Secondly, Kate never does an Internet search for her would-be love. As a veteran of a long distance relationship, I can attest that pictures are the lifeblood of such interaction. First, despite all their correspondence, these two never send pictures. ![]() Two things in particular bothered me about this film, and neither had to do with its preposterous premise. The romance, which is delicately developed as these two people reach out across the years to each other, is effective, but there's almost too much baggage. Don't think too hard - you'll spoil the mood. If you choose to see The Lake House, you have to accept it as a fairy tale, time travel paradoxes and all. In for a penny, in for a pound, they say. For her part, Kate waits patiently for Alex to "catch up" to her. ![]() Eventually, seeking to meet his soulmate, Alex seeks out Kate's 2004 counterpart. The fact that their letters are traveling through time doesn't seem to bother them. ![]() They "meet" and begin exchanging correspondence via the house's mailbox. Both live in an extravagant, glass walled house on the shore of Lake Michigan - he in 2004 and she in 2006. The Lake House is about the unlikely love affair between two lonely people: Alex (Keanu Reeves) and Kate (Sandra Bullock). How many foreign films, when "translated" into English, find their endings mangled or made over in order to pander to "mainstream" sensibilities? (Ironically, the ending of Il Mare was criticized in some circles for being too upbeat, although apparently not upbeat enough for Warner Brothers, which remove all vestiges of ambiguity.) The final scene, however, is lifted not from the original but from the Hollywood shelf of cheap cop-outs. The Lake House is based on the 2000 South Korean film Il Mare, which I have not seen. And for those who attempt to apply logic to this movie, everything will come crashing down like a poorly balanced house of cards. Unfortunately, trying doesn't necessarily mean succeeding and, even for those who buy into the basic ideas, there are credibility gaps that The Lake House cannot surmount. As premises go, this has the virtue of uniqueness - Hollywood doesn't churn out time-traveling mailbox movies on a regular basis. ![]() Although this may amount to oversimplification, Alejandro Agresti's The Lake House is essentially a romance between two people connected by a time-traveling mailbox. ![]() ![]() If you believe that any item of information contained in your NCTUE Disclosure Report is incomplete or inaccurate, notify our team directly and if warranted, we will investigate the matter with the source that provided the information – free of charge. How can I correct or dispute inaccuracies in my NCTUE Disclosure Report? ![]() ![]() ![]() ![]() |